Who We Are
People
Principal Investigator (Singapore)
Kimberly Kline
MPH PhD, NTU Biological Sciences, Singapore Centre for Environmental Life Sciences Engineering (SCELSE)
Kimberly.Kline@unige.ch
Kimberly was born and raised in the state of North Dakota in the USA. She earned her PhD from Northwestern University and did her post-doc in the laboratory of Scott Hultgren at Washington University in St. Louis in collaboration with Birgitta Henriques-Normark and Staffan Normark at the Karolinska Institute in Stockholm. During that time, Kim was an American Heart Association Fellow, Carl Tryggers Fellow, and NIH K99 recipient. In 2014, Kim was awarded an ICAAC Young Investigator Award by the American Society of Microbiology.
The Kline research groups are working to understand the bacterial virulence factors that contribute to colonization, biofilm formation, and infection by E.faecalis and related pathogens.
Research
Mechanisms of focal virulence factor assembly
Gram-positive & Polymicrobial Interactions in UTI and Wound Infection
Pathogen-host interactions important during Group A Streptococcus biofilm formation
AMR IRG projects interrogate biofilm-associated infections from various perspectives including genetic perturbations using parallel combinatorial genetics, by harnessing macrophage responses, through nanoparticle-based biofilm-penetrating therapies, and through analyses of the epitranscriptomic regulation of phenotypic resistance.