Our Work

The AMR IRG Approach

Our projects within the AMR IRG range from fundamental microbiology through the understanding of resistance mechanisms and host-pathogen relationships, to the development of novel diagnostics and therapeutics that can be progressed towards clinical translation.

We’re diagnosing and treating AMR in the human microbiome.

We’re engineering viruses to kill AMR bacteria.

We’re engineering antibodies against AMR.

We’re building new drugs for resistant microbes.

We’re harnessing the power of the human immune system.

We’re creating fast, cheap, and easy AMR diagnostics.

We’re designing nanoparticles to kill bacteria hiding in biofilms.

Projects

Targeting signaling networks that govern biofilm-associated infection

Timothy Lu, Kimerbly Kline

Enhancing macrophage reactivity for effective elimination of microbes

Jianzhu Chen, Kimberly Kline

Antibody development for targeting drug-resistant microbes

Ram Sasisekharan, Eng Eong Ooi

Effects of clinically relevant antibiotics on the microbiome

Eric Alm, Eng Eong Ooi, Jenny Low, Andrea Kwa, Shirin Kalimuddin, Raphael Zellweger, Thuan Tong Tan

Nanotechnology against AMR

Paula Hammond, Mary Chan, Kimberley Kline, Kevin Pethe

The role of the epitranscriptome in antimicrobial resistance in malaria parasites

Peter Dedon, Peter Preiser

A modular vaccination platform using multivalent presentation of antigens

Julien Lescar, Peter Dedon, Kimberly Kline, Peter Preiser

Discovering epitranscriptomic drug targets in Enterococcus faecalis biofilm formation

Peter Dedon, Kimberly Kline

Fecal microbiota transplant (FMT) for eradication of carbapenem-resistant Enterobacteriaceae gut colonization: a pilot, randomized-controlled trial

Eric Alm, Oon Tek Ng, Marimuthu Kalisvar

Design of a diagnostic test for bacterial versus viral upper respiratory infections

Hadley Sikes, Tsin Wen Yeo

Antimicrobial resistance profiling of low-abundance pathogens in biofluids

Jongyoon Han, Peter Preiser

Phage lysin engineering platform

Goh Boon Chong

Wastewater-based surveillance for rapid outbreak detection and intervention

Eric Alm