People

Michelle received her Ph.D. in chemistry from Vanderbilt University (U.S.A.) where she studied the allosteric regulation of cyclooxygenase-2 (the target of non-steroidal anti-inflammatory drugs) by two of its lipid/lipid-derivative substrates. Here she also performed research on peroxidation-derived DNA adducts, investigating their correlation with oxidative stress and their metabolic fates. She then carried out postdoctoral work at Princeton University (U.S.A.) investigating the biochemical and cellular consequences of cancer-associated histone mutations. Upon relocation to Singapore, she joined the SMART AMR IRG in the lab of Prof. Peter C. Dedon where she currently studies the role of tRNA modifications in Enterococcus faecalis biofilm formation in collaboration with Prof. Kimberly Kline